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Furthermore, although its very rare, getting too much vitamin B12 can lead to toxicity, says Yuval Pinto, MD, an obesity and family medicine doctor at Johns Hopkins Medicine in Baltimore

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Note, however, that most of this research was aimed at in-depth analyses of specific forms of homosynaptic plasticity, and experimental conditions were optimized for the induction of these specific plasticity forms, e.g., induction protocols applied at hyperpolarized membrane potentials to maximize calcium influx via CP-AMPARs, and/or recordings were made with cesium-based intracellular solution and added sodium channel blocker QX-314 for better voltage control