Peripheral-nerve transection and crush models Here a rodent sciatic (or facial) nerve is cut or crushed, then repair is tracked with the sciatic functional index (a walking-track measurement of toe spread), electromyography, and histomorphometry counting the number, diameter, and myelination of regenerating axons
Della Pepa, G
6 Since the IGF-1R signaling pathway is critical for the development, maintenance, and survival of cancers, many small molecule compounds and antibodies targeting IGF-1R have been developed
For other PD-associated variants, e.g., GBA and LRRK2 , their role in progressive -synuclein accumulation is less clear, although they have been associated with mitochondrial (dys)function and/or protein degradation pathways 6,7,8