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The metal chelating activity of flavonoids results either (i) in the formation of metal-chelates which have lower catalytic efficiency in Fenton reaction than pure flavonoids (decreased number of metal binding sites is usually associated with lower catalytic activity) or (ii) metal flavonoid chelates can intercalate into DNA of cancer cells, triggering cell death (Simunkova et al

NobariHGandomaniEEReisiJVahabidelshadRSuzukiKVolpeSLet al

tricolor , approximately 24 phenolic compounds have been identified, including nine major flavonoids: quercetin, isoquercetin, hyperoside, rutin, kaempferol, myricetin, apigenin, catechin, and naringenin

They may act in other target organs, in nearby cells, or in the same cell