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Getting B12 injections is like hitting a reset button your body can suddenly get back to converting food to energy efficiently

Since cell proliferation is influenced by multiple regulatory pathways, including metabolic state, mitochondrial function, and redox balance, additional mechanisms beyond ferroptosis likely contribute to this phenotype

Our findings, which utilize a novel CSMN reporter line with TDP-43 pathology, not only reveal the presence of metabolomic defects at an early stage of the disease, but also suggest that proper modulation of metabolomic imbalance could offer therapeutic strategies to improve the integrity of mitochondria, and thus the health of diseased UMNs