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Because creating glutathione and fighting ROS is highly energy-dependent, the immune system consumes massive amounts of the host's ATP

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However, when ROS production exceeds the cellular antioxidant capacity, oxidative stress ensues, leading to damage of proteins, lipids, and DNA

Increasing acknowledgment exists that varying regional regulationssuch as those in the European Union, United States, and Asia-Pacificpose challenges to global market access, generate heterogeneity in permitted terminology (including the use of the term probiotic), and hinder the dissemination of consistent, evidence-based information to healthcare professionals and consumers (513)