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Similarly, Chen et al.30 did a cross-sectional study between the years of 1996 and 1997 assessing 73,364 Canadian individuals

They also found that lower quality studiesranked using the Newcastle-Ottawa Scaletended to report positive associations and had greater between-study variance ( 2 = 0.2) while higher quality studies tended to report null findings and had lower between-study variance ( 2 = 0.01) [116]

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Nicotine and cotinine levels can be measured through various tests, including blood, urine, saliva, and hair samples