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TRPV6 mediates the major pathway of calcium transcellular absorption in the gastrointestinal tract, while TRPV5 is primarily located in the renal nephron at the distal tubules and collecting ducts, which are the sites of renal calcium reabsorption

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Recent studies have all demonstrated important heterogeneity in macrophage phenotype and function, but the specific mechanisms by which STMs subsets that might amplify the inflammatory response or promote the restoration of tissue homeostasis are unclear (You et al., 2021