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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

Reiner, D

A 2018 study in Toxicology Letters (hepatocyte cell model) found that co-exposure to isotretinoin and high-dose EGCG (50 M each) reduced cell viability by 38% compared to either compound alone at the same dose [8]

Stress, environmental pollution, diseases, inflammations or an unbalanced diet can also lead to an increased glutathione consumption in the cells