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Macroscopically, a degenerated disc contains annulus fissures 8 , and/or endplate defects 9 , and microscopic changes include accelerated loss of water-retaining glycosaminoglycan (GAG) molecules 10 , nerve and blood vessel infiltration 11 , cell clustering 12 , and upregulation of matrix-degrading enzymes 13

The shortage of novel antifungal drugs under development needs the creation of potent antifungal agents, particularly those derived from natural ingredients