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How Ipamorelin Compares to Other GH Secretagogues The selectivity pattern is clear: ipamorelin occupies a unique position as the only GHRP with GHRH-like hormonal selectivity while acting through the GHS-R1a receptor rather than the GHRH receptor

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Tesamorelin acts primarily through the GHRH receptor in the anterior pituitary, while Ipamorelin selectively targets the ghrelin/growth hormone secretagogue receptor, known as GHS-R1a