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Also observed a significant increase in cytochrome P450 (CYP)-CYP1A1/2, CYP2B1/2 and CYP3A to an enhanced cancer risk from the widely bioactivated e-cig vapour procarcinogens associated with an increased risk of lung cancer with CYP induction and/or CYP polymorphisms (Table 3)

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The Biological Reality Both expose lungs to: Oxidative stress Inflammatory cytokine activation Epithelial barrier dysfunction Impaired mucociliary clearance What I Tell My Patients If the question is: Is vaping safer than smoking? The honest medical answer is: Vaping may reduce exposure to some carcinogens compared to traditional cigarettes but it introduces new chemical risks and does not make inhalation safe

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