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In the case of I/R injury, systemic inflammation and the release of cytokines and LPS can enhance BBB permeability by breaking tight junctions between endothelial cells and by activating matrix metalloproteinases that breakdown the extracellular matrix (S-Pereira et al., 2012)

Its health benefits-spanning cardiovascular, neurological, metabolic, and anti-inflammatory domains-are primarily mediated through antioxidant, anti-inflammatory, pro-apoptotic, and signaling pathway modulation mechanisms, as summarized in Table 1

Coenzyme Q10 Supplementation in Aging and Disease

For instance, silica-coated magnetic nanoparticles suppressed proteasome gene expression and activity, while promoting cytoplasmic inclusion formation in SH-SY5Y cells and primary neurons in a dose-dependent manner (Nie et al., 2021)