Evidence of secondary coenzyme Q 10 deficiency has been reported in several mitochondrial disorders, such as mitochondrial DNA depletion syndrome, Kearns-Sayre syndrome, or multiple acyl-CoA dehydrogenase deficiency (MADD) (10)
Destructive cholangitis is characterized histopathologically by a loss of bile ducts (ductopenia) within the smaller portal areas, associated with cholestasis, portal inflammation consisting primarily of macrophages, neutrophils, and occasionally eosinophils, and progressive portal fibrosis.1, 31, 32 This is a rarely reported lesion of unknown etiology
Iqbal MS, Rahman S, Haque MA, Bhuyan MJ, Faruque ASG, Ahmed T
The bioavailability of most commercially-available products is problematic, and some have not been tested in children