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When DHT levels remain high, its androgenic effects continue to exert negative pressure on hair follicles, potentially overpowering the positive effects induced by the growth factors in PRP

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These include disturbances in serotonergic neurotransmission or the HPA axis, alterations in adult hippocampal neurogenesis or brain region integrity, activation of systemic pro-inflammatory processes or neuroinflammation, or by the triggering of the kynurenine pathway