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Among drugs that have been approved in recent years, the average share of females in the trial population has been consistently reported since 2014 by the FDA, with the average share of 51 percent between 2014 and 2021, ranging from 37 percent in 2014 (six trials) to 57.1 percent in 2019

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However, for conditions like stubborn melasma, the success rate drops by 20% to 30% if broad-spectrum SPF is not reapplied every two hours, as summer UV rays can quickly trigger rebound pigmentation

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