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They also reported that treatment with urolithin A prior to sleep deprivation blunted the overactivation of glial cells, attenuated the increase in pro-inflammatory cytokines (IL-6, TNF- ), and maintained mitochondrial dynamics and morphology integrity in the hippocampus, a brain region highly susceptible to sleep deprivation-induced deficits (40)

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This approach would guide targeted interventions such as specific antioxidant therapies or lifestyle modifications prior to assisted ART