& Dow, S
J Ethnopharmacol 246:112205 Arajo LCC, Aguiar JS, Napoleo TH et al (2013) Evaluation of cytotoxic and anti-inflammatory activities of extracts and lectins from Moringa oleifera seeds
While the importance of endothelial dysfunction in cardiovascular disease is well accepted, most evidence suggests that the primary mechanism by which this occurs is via oxidative stress in which superoxide either directly inactivates NO (by forming peroxynitrite), uncouples the endothelial NO synthase, or passively increases an inhibitory substrate (asymmetric dimethylarginine) by inhibiting the enzyme, dimethylarginine dimethylaminohydrolase.[18] In this regard, UA has been shown to help preserve endothelial NO levels via its role as an antioxidant, either by blocking the uncoupling of endothelial NO synthase by reacting with peroxynitrite,[18] or by preventing the oxidant-induced inactivation of extracellular superoxide dismutase.[19] A paradox then develops, for how can UA, which is the most abundant (about six times as ascorbate) antioxidant in plasma,[6] induce endothelial dysfunction in vivo
CrossRef Sea buckthorn (Hippophae rhamnoides L.) oil enhances proliferation, adipocytes differentiation and insulin sensitivity in 3T3-L1 cells Ting Zhang, Xuze Qin, Yuxin Cao, Jianxin Zhang, Junxing Zhao Food Science and Biotechnology.2020
