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Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2004 [accessed 2019 July 29]

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This effect can lead, at least short term, to intense feelings of depression and anhedonia, in which a person cannot experience pleasure when a chemical component isnt there to induce it

Wootton and colleagues then used two separate genetic databases, one including thousands of individuals with schizophrenia and the other including thousands of individuals with major depression, to explore whether the risk of having such conditions was linked to the genetic variants for smoking