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Injecting slowly, over 20 to 30 seconds rather than in a single rapid push, allows the surrounding subcutaneous tissue more time to equilibrate as the solution is introduced

Across multiple experimental settings, these agents demonstrate biologic activity involving angiogenesis, inflammatory modulation, fibroblast migration, and collagen remodeling

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Commons RJ, Simpson JA, Thriemer K et al (2019) The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis