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Occasionally, users report headaches or dizziness, particularly during initial use

These events mitigate cellular reductive stress by suppressing key metabolic pathways, indicating a crucial role of L-2-HG

In older adults (aged 6376), higher MedDiet or MIND scores are associated with healthier brain structural markers, such as larger gray matter or hippocampus volume, and thicker cortex, which result in improved memory performance [206, 211]

Another advantage is that its excretion is handled more by the liver than the kidney, unlike allopurinol, and febuxostat may thus have some advantage in patients with kidney dysfunction