IGF-1 increases muscle mass and muscle functional capacities
As a whole, under hyposalinity, the content of GSH, AsA and cysteine, and the activity of GPX, APX, -GCS and MDHAR increased, while the content of GSSG and DHA and the activity of GR and GST decreased, leading to the increase ratios of GSH/GSSG and AsA/DHA
Prolonged IGF-1 elevation may interfere with insulin signaling pathways, resulting in glucose metabolism disruption and increased diabetes risk. Clemmons, The Journal of Clinical Endocrinology & Metabolism Cell Overproliferation and Cancer Concerns IGF-1 promotes cell growth and replication , which is great for musclebut not ideal in individuals with: A history of cancer A family history of hormone-sensitive tumors Undiagnosed growths or cysts IGF-1 is considered mitogenic , meaning it encourages cell division
However, BSO induced cell death to a lesser extent with slower kinetics