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Findings from a systematic review and meta-analysis of randomized clinical trials

In addition to this study in patients with bronchiectasis, studies of brensocatib in other indications, such as CRSsNP (NCT06013241), are underway

Phase 1 is believed to correspond to the high level of activity in the primary afferent as by C-fiber activation due to peripheral stimulation, 9 whereas phase 2 seems to result from the continuous low level of small afferent input, together with a facilitated state of spinal processing