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Semaglutide (Wegovy) is FDA-approved for chronic weight management (with criteria) and has strong clinical trial evidence for meaningful average weight loss when paired with lifestyle support

The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

(109) found that cashew protein hydrolysate inhibited the production of pro-inflammatory cytokines in the brain of rats with arterial occlusion-induced cerebral is chaemia, and by modulating the function of lipid metabolism, its modulation of serum cholesterol, TG, and LDL, and elevation of HDL, greatly improved spatial memory in rats

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