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Metabolomic studies in the preclinical ischemic AKI model have shed substantial light on this issue and demonstrated widespread changes in energy metabolism in the kidney as well as remote organs including the heart and lung 6,15, 16

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Hollow microneedles add a fourth mechanism that solid microneedles cannot: the molecule is delivered during channel formation, not after

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Moreover, OCTN2 mediates the tissue distribution of carnitine, ensuring that these tissues receive sufficient carnitine to maintain their normal functions [164]

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Clinics (2018) 73(suppl 1):e473s

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