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We do not know the optimal dose for endometriosis benefit

This could in part be due to the lower levels of ApoE in the CNS of ApoE4 carriers (Flowers and Rebeck, 2020), thus offering less overall antimicrobial protection, but also mechanistically as ApoE4 prevents HSV-1 cellular attachment but crucially not viral entry or replication, and can also be incorporated into the HSV-1 virion that can enhance release from the cell (Feng et al., 2023), which would be an issue for viral AD

If pharma lobbies hard enough and they're able to get this done, like what they wanna do, reclassifying all these as biologics, it allows them to extend the patent for 10 to 12 years

PMC10056213 Subcutaneous injection osmolality, pH, and volume effects on pain and absorption