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Monoamine Oxidase (MAO) Inhibition: Although its clinical relevance is debated, at high doses amphetamine acts as a weak competitive inhibitor of monoamine oxidase, the mitochondrial enzyme responsible for degrading free cytosolic monoamines

It has been postulated before that either residue Sec498 hTrxR1 or residue Cys497 hTrxR1 attacks the intra-molecular hTrx1-disulphide (Cys32 hTrx1 , Cys35 hTrx1 ), forming an inter-molecular disulphide bond between hTrx1 and hTrxR1 during catalysis 23

Comparison of heroin and cocaine concentrations in saliva with concentrations in blood and plasma