inducible NOS (also known as iNOS, type II, NOS-II, and NOS2), being the isoform which can be synthesized following induction by pro-inflammatory cytokines or endotoxin and endothelial NOS (also known as eNOS, type III, NOS-III, and NOS-3), being the isoform expressed in endothelial cells (Murphy et al., 1993
a number of the agonists in Table 1 (Families 2-5) have norleucine at Rj, or an amino acid residue a number of an amino acid residues (D or L) may be used at residue Ri, including without limitation, tyrosine, phenylalanine, aspartic acid, arginine, isoleucme, serine, histidine, glycine, cysteine, methionine, tryptophan, norvaline, ornithine, S-benzyl cysteine amino acid residues
[DOI] [PubMed] [Google Scholar] 82.Katoulis A.C., Liakou A.I., Koumaki D., Vakirlis E., Tsantes A.G., Mortaki D., Bozi E., Ioannides D
Excellent tolerance with minimal side effects doesn't justify accelerating the escalation schedule