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5% due to alternative cytochrome P450 depending glutathione (GSH) conjugation pathway At high doses : Glucuronidation and sulfation pathways become saturated Cytochrome P450 dependent pathway becomes now more important.With depletion of hepatic glutathione, hepatotoxic, reactive, electrophilic metabolites are formed

Consequently, when system Xc is inhibited, the diversion pathway can counteract ferroptosis resulting from system Xc inhibition [146]

Figure 9 The addition of exogenous GSH or BSO had similar effect on the GSHGSSG cycle, i.e., the content of GSH increased while the GSSG content and GR activity decreased under 30 psu (100% seawater, control)

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