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These flavonoids, in addition to interfering with the activities of P-gp, also downregulated its expression [203]

Thus, nasal delivery devices like powder devices, dry powder inhalers, bidirectional breath-powder delivery devices, meter-dosed spray pumps, nasal sprays, pressurized meter-dosed spray inhalers, nebulizers, atomizers, and pressurized olfactory devices have proceeded to clinical trials

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Among these, three achieved pregnancy with one live birth, demonstrating the efficacy of MenSCs in improving endometrial function and fertility outcomes (Malik et al., 2018