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DOX-induced cardiotoxicity is driven by established mechanisms, such as oxidative stress, and centrally by dysregulated copper homeostasis and cuproptosis

The typical intake for the vitamin is about 2.4 mcg daily, however it can be higher from women when they are going through pregnancy or feeding a newborn

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Microglia are transformed into DAM by recognizing Neurodegeneration-Associated Molecular Pattern (NAMP) danger signals which leak from damaged neuronal cells in analogy to the peripheral immune systems pathogen- and damage-associated stress signals (PAMPs and DAMPs) 23