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First, whereas the human and murine pathology emanates from a single supra-therapeutic dose of APAP, we only observed significant mortality after continuous ad-lib exposure

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However, the frequency of the responses was low and the responses reported were inconsistent and were not reproducible . In other words, they did not pass the basic test of scientific credibility reproducibility

In recent years, the pathophysiological mechanisms of early brain injury (EBI) after SAH have become the hotspot of experimental and clinical research, and EBI is the key factor of poor prognosis of SAH