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The 2004 Bissett study in International Journal of Cosmetic Science used twice-daily 5 percent niacinamide for 12 weeks in 50 women aged 40 to 60, documenting significant reductions in fine lines, hyperpigmentation spots, blotchiness, and yellowing [13]

Without public access to the methodology, detailed results, and pharmacokinetic data, the clinical community cannot independently scrutinize and validate the findings

Desuccinylases primarily encompass SIRT5 and SIRT7 [82], as well as the HDAC family, with HDAC1/2/3 primarily mediating the desuccinylation of histones [83]

The role of EZH1 and EZH2 in development and cancer