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Although beyond the primary scope of this review, it is worth mentioning that emerging evidence highlights the gut microbiome as a potential mediator of circadian disruption-associated breast carcinogenesis, with studies indicating that NSW can alter microbial composition and diurnal rhythmicity, thereby modulating systemic inflammation, estrogen metabolism, and immune function, all of which are relevant to BC risk 260

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While cross-species analyses are commonly used to explore shared biological mechanisms, it is important to recognise that mice and humans have differences in gene expression, metabolism and bone biology

There is no one size fits all formula and each brand may have different ingredients