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Isotopic tracing with 15N-labeled glutamine revealed that 57% of ammonium is recycled via GDH-mediated reductive amination, generating 15N-labeled amino acids (excluding proline and glutathione, which are synthesized directly from glutamate) (83)

Phosphoribosyl pyrophosphate synthetase 1 (PRPS1), the key enzyme of the de novo nucleotide synthesis pathway, is O -GlcNAcylated by O -GlcNAc transferase (OGT), which triggers PRPS1 hexamer formation and relieves nucleotide product-mediated feedback inhibition, thereby boosting PRPS1 activity

SAG S-acetyl-glutathione a method for increasing circulating and/or intracellular levels of glutathione comprises orally administering to an individual in need thereof a delayed-release, gastro-resistant capsule which contains an amount of S-acetyl-glutathione (SAG) effective to increasing circulating and/or intracellular levels of glutathione

The anti-leukemic effect of TMQ0153 was generalized through colony formation assays using the AML cell lines MV4-11, U937, HL60, and THP-1 (Fig