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Animal Model:Wistar Albino (male, 200-220 g body weight) [3] Dosage:10 g/kg, 10 ng/kg (catalepsy and gastric ulcers)

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[ 478 ] However, many natural NRF2 agonists are unstable under physiological conditions, with extremely low bioavailability, [ 479 ] and their reactions with cysteine residues are often irreversible, which can cause abnormal and persistent activation of NRF2 and may lead to carcinogenesis, [ 480 ] severely limiting their clinical application

10.1038/nature13148 94 MancusoR