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This number, 0.4368 nM, is the average E 2 over the menstrual cycle computed from the data in Panel A of Figure 2

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Semaglutide solves this problem through three key molecular modifications engineered to dramatically extend its biological activity while preserving high-affinity GLP-1 receptor (GLP-1R) binding: Amino acid substitution at position 8 Alanine is replaced with 2-aminoisobutyric acid (Aib) , making the molecule resistant to DPP-4 enzymatic degradation

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