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Malic Enzymes (ME) The synthesis of NADPH via the action of malic enzyme is directly coupled to the process of the transport of acetyl-CoA from the mitochondria to the cytosol where the acetyl-CoA can then be used for fatty acid synthesis, cholesterol synthesis, phospholipid synthesis, and deoxynucleotide synthesis as indicated above

McQuinn and Waters 2024)

Clinically, HSV-1 infection is usually shown in oral niches and HSV-2 infection is often observed in genital niches (Rathbun and Szpara, 2021)

Additional molecular evidence indicates NSW induces a state of circadian misalignment marked by upregulation of key clock genes including BMAL1, CLOCK, PER1, PER2, and PER3