Smoked or chewed in small amounts by those who can identify which plant to use and how to use it, coyote tobacco ( Nicotiana attenuata ) may be hallucinogenic, and was once used in folk medicine to help alleviate pain
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The impact it had on the two hemispheres was both positive and negative
It is unknown why smoking is always deleterious rather than beneficial, even though it exerts dual effects on immune responses
