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doi: 10.1088/1755-1315/910/1/012044 50 AltmannBAWiggerRCiuluMMrleinD

H 2 O 2 signaling leads to the release of Nrf2 from complexes with Kelch-like ECH-associated protein 1 (Keap1) and ubiquitin ligase Cullin 3 and into the nucleus, where it binds to antioxidant response elements (ARE) and activates the expression of its target gene GPX8, which in turn regulates the expression of ER calcium by regulating SERCA (Granatiero et al., 2019)

Rapeseed peptide is another plant-derived bioactive peptide with anticancer properties induced by apoptosis (31)

Oxidative post-translational modifications develop LONP1 dysfunction in pressure overload heart failure