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Furthermore, SGLT2i activate autophagy, a pathway that, when deregulated, contributes to kidney damage, by inhibiting mTOR signaling and activating adenosine monophosphate-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) [155, 165, 171]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Furigo IC, de Souza GO, Teixeira PDS, Guadagnini D, Frazao R, List EO, Kopchick JJ, Prada PO, and Donato J, Jr

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