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Summary of Imaging Findings in Bipolar Disorder Cumulative imaging evidence of functional, structural, and white-matter abnormalities implicates a compromised integrity of frontalsubcortical and prefrontallimbic circuits in the pathophysiology of bipolar disorder

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Notably, geldanamycin, an Hsp90 inhibitor, blocked NOS1 mitochondrial translocation, reversing its anti-apoptotic effects and restoring chemosensitivity