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Developing predictive in silico and in vitro systems incorporating functional drug antigens, genetics of the susceptible patients, and factors that modulate immune function is urgently needed to identify those candidates with high risk of immunogenicity at early stages of drug discovery

Hart, P

This study led to the identification of two novel candidate effector genes, SPRY4 and PAPPA (pregnancy-associated plasma protein A), these genes may be involved in gene regulation through enhancer-promoter interactions [26]