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Proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) are commonly prescribed after bariatric surgery and can impair the release of B12 from food proteins, reducing absorption of food-bound B12 over time

Have questions about vitamin B12 injections

On-Label vs Off-Label and Compounded Products Vitamin B12 injections are an established medical treatment for confirmed B12 deficiency and related conditions (for example, pernicious anemia and certain malabsorption states), as summarized by the NIH Office of Dietary Supplements in its Vitamin B12 fact sheet for health professionals

Those with severe deficiencies may receive more frequent Optimal B12 injection dosage for adults at first before tapering frequency