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DOI: 10.1161/HYP.0000000000000065 Wimalasena K (2011): Vesicular Monoamine Transporters: Structure-Function, Pharmacology, and Medicinal Chemistry

The depot effect in subcutaneous adipose tissue isn't a limitation

(PubMed) Brace LD

L-Lysine is able to cross the blood-brain barrier and reach a part of the brain where it is metabolised into -aminoadipic acid, which can interact with a number of neuroreceptors (1)