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In order to detect the effect of AMSCs therapy on mitochondrial function, we selected the time point (6 h) when mitochondrial damage is significant after APAP injection for the experiment [38]

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In addition to its role in oxidizing macromolecules such as proteins and lipids, H 2 O 2 has also been proposed to function as a signal to induce the expression of genes involved in the senescence process ( Arabidopsis could be induced by ozone (Miller et al., 1999) and the expression of many other SAGs were also induced by ROS (Navabpour et al., 2003), indicating that ROS might function as a signal to promote senescence