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The distinct mode of CTR and AMYR engagement by Cagri revealed in the current study, together with the correlated distinctions in functional responses at individual receptors, is likely to be important in the differentiated, high efficacy, of Cagri as a first-in-class obesity drug in both preclinical animal models and in treatment of obese patients in clinical trials 2,3,4

The dual functionality of LOXs, which exhibit both dioxygenation and HPI activity, expands the catalytic repertoire of these enzymes but also poses challenges in product purification