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Human observational data in elderly subjects suggests it restores nighttime melatonin in those with low baseline levels without causing overshoot in those with normal function

Pasteur et al., 2010

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Thus, in the mouse, early separation from the dam leads to changes in DNA methylation, resulting in increased PVN AVP expression and changes in coping responses to stress ( In addition to the early influence of stress and glucocorticoids directly on the HPA axis, stress and glucocorticoids can also independently influence development of the feeding circuitry discussed above