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Elderly patients: Older adults may experience enhanced effects from both medications due to slower metabolism and increased sensitivity

On the whole, the pharmaceutical industry not only looked the other way when it came to smoking, but at least one company, Merck Sharp and Dohme, encouraged it by sending personally embossed matchbooks to physicians with ads for its new antihypertensive medications, DIURIL (chlorothizaide) and HYDRODIURIL (hydrochlorothiazide)

In some individuals, it may trigger mania or hypomania, especially if there is an underlying bipolar disorder

There is no sudden increase in dryness or scratchiness halfway through