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These strategies may involve diverse mechanisms in glial cells and neurons, including inhibition of apoptosis, reduction of excitotoxicity, suppression of neuroinflammation, enhancement of mitochondrial function, or promotion of neuronal regeneration [565, 566]

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Even in acquired thyroid disease, regional differences in transporter expression may explain the selective vulnerability of hippocampal and cortical circuits to hormone fluctuations (55)

Copper Transport and Bioavailability Copper is an essential cofactor for lysyl oxidase, superoxide dismutase, and several other enzymes critical to connective-tissue assembly and redox balance