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Sonthalia, S.,et al (2016) Vitamin C -Ascorbic Acid (vitamin C, AsA), is the most plentiful antioxidant in human skin The idea behind using antioxidants for skin-lightening activities lies in the hypothesis that the oxidative effect of UV-irradiation contributes to activation of melanogenesis As it interferes with melanin synthesis -reducing oxidized dopaquinone -interrupting DHICA oxidation -preventing action of tyrosinase Int J Mol Sci

After menopause when the ovaries stop producing measurable levels of estrogens, the stromal cells of adipose tissue, including the breast, become the main site of estrogen biosynthesis ( CYP19A1 gene, is the enzyme responsible for catalyzing the final and key step in estrogen biosynthesis by converting androgens into estrogens

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Benabe JE, Echegoyen LA, Pastrana B, Martnez-Maldonado M